Human and mouse chromosomal mapping of the myeloid cell leukemia-1 gene: MCL1 maps to human chromosome 1q21, a region that is frequently altered in preneoplastic and neoplastic disease.

摘要: The MCL1 gene, recently identified in a myeloid leukemia cell line, has sequence similarity to BCL2, the gene at t(14;18) translocation follicular lymphoma. chromosomal location of now been determined. human locus (MCL1) was mapped long arm chromosome 1q21, using methods situ hybridization and somatic hybrid analysis. In mouse, MCL1-related sequences were positions on two mouse chromosomes (chromosomes 3 5), haplotype analysis an interspecific cross. (Mcl1) homologous that 1; second (Mcl-rs 5) may represent pseudogene. proximal 1, where is located, duplicated and/or rearranged variety preneoplastic neoplastic diseases, including hematologic diseases solid tumors. thus candidate for involvement cancer.