A review of patents (2011–2015) towards combating resistance to and toxicity of aminoglycosides
作者： Nishad Thamban Chandrika , Sylvie Garneau-Tsodikova
DOI: 10.1039/C5MD00453E
关键词: Efflux 、 Repurposing 、 The Renaissance 、 Streptomycin 、 Toxicity 、 Medicine 、 Antibiotic resistance 、 Antibiotics 、 Pharmacology
摘要: Since the discovery of first aminoglycoside (AG), streptomycin, in 1943, these broad-spectrum antibiotics have been extensively used for treatment Gram-negative and Gram-positive bacterial infections. The inherent toxicity (ototoxicity nephrotoxicity) associated with their long-term use as well emergence resistant strains limited usage. Structural modifications AGs by AG-modifying enzymes, reduced target affinity caused ribosomal modification, decrease cellular concentration efflux pumps resulted resistance towards AGs. However, last decade has seen a renewed interest among scientific community exemplified recent influx articles patents on therapeutic use. In this review, we non-conventional approach to put forth renaissance AG development/application summarizing all filed from 2011–2015 highlighting some related publications most work done overcome improving while reducing ototoxicity nephrotoxicity. We also present developing amphiphilic fungicides that repurposing existing potential newer applications.
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sci-hub.se 参考文章(214)
Chien-Hung Chou, Chung-Shieh Wu, Ching-Hui Chen, Lung-Dai Lu, Suvarn S. Kulkarni, Chi-Huey Wong, Shang-Cheng Hung, Regioselective Glycosylation of Neamine Core: A Facile Entry to Kanamycin B Related Analogues Organic Letters. ,vol. 6, pp. 585- 588 ,(2004) , 10.1021/OL0363927
Cheng-Wei Tom Chang, Yu Hui, Bryan Elchert, Jinhua Wang, Jie Li, Ravi Rai, Pyranmycins, a Novel Class of Aminoglycosides with Improved Acid Stability: The SAR of d-Pyranoses on Ring III of Pyranmycin Organic Letters. ,vol. 4, pp. 4603- 4606 ,(2002) , 10.1021/OL0269042
So Ha Lee, Chan Seong Cheong, Selective reactions of reactive amino groups in polyamino compounds by metal-chelated or -mediated methods Tetrahedron. ,vol. 57, pp. 4801- 4815 ,(2001) , 10.1016/S0040-4020(01)00297-6
Jie Li, Jinhua Wang, Przemyslaw Greg Czyryca, Huiwen Chang, Thomas W. Orsak, Richard Evanson, Cheng-Wei Tom Chang, Application of glycodiversification: expedient synthesis and antibacterial evaluation of a library of kanamycin B analogues. Organic Letters. ,vol. 6, pp. 1381- 1384 ,(2004) , 10.1021/OL0497685
Jianjun Zhang, Katherine Keller, Jon Y Takemoto, Mekki Bensaci, Anthony Litke, Przemyslaw Greg Czyryca, Cheng-Wei Tom Chang, Synthesis and combinational antibacterial study of 5″-modified neomycin The Journal of Antibiotics. ,vol. 62, pp. 539- 544 ,(2009) , 10.1038/JA.2009.66
Annie Rebibo-Sabbah, Igor Nudelman, Zubair M. Ahmed, Timor Baasov, Tamar Ben-Yosef, In vitro and ex vivo suppression by aminoglycosides of PCDH15 nonsense mutations underlying type 1 Usher syndrome Human Genetics. ,vol. 122, pp. 373- 381 ,(2007) , 10.1007/S00439-007-0410-7
HB Lee, Y Kim, JC Kim, GJ Choi, S‐H Park, C‐J Kim, HS Jung, None, Activity of some aminoglycoside antibiotics against true fungi, Phytophthora and Pythium species. Journal of Applied Microbiology. ,vol. 99, pp. 836- 843 ,(2005) , 10.1111/J.1365-2672.2005.02684.X
Sharanabasava B. Rajur, Jordi Robles, Kristin Wiederholt, Robert G. Kuimelis, Larry W. McLaughlin, Hoechst 33258 Tethered by a Hexa(ethylene glycol) Linker to the 5'-Termini of Oligodeoxynucleotide 15-Mers: Duplex Stabilization and Fluorescence Properties. Journal of Organic Chemistry. ,vol. 62, pp. 523- 529 ,(1997) , 10.1021/JO9618536
Emmanuel Riguet, Jérôme Désiré, Oliver Boden, Verena Ludwig, Michael Göbel, Christian Bailly, Jean-Luc Décout, Neamine dimers targeting the HIV-1 TAR RNA Bioorganic & Medicinal Chemistry Letters. ,vol. 15, pp. 4651- 4655 ,(2005) , 10.1016/J.BMCL.2005.07.082
Derrick Watkins, Sunil Kumar, Keith D. Green, Dev P. Arya, Sylvie Garneau-Tsodikova, Influence of Linker Length and Composition on Enzymatic Activity and Ribosomal Binding of Neomycin Dimers Antimicrobial Agents and Chemotherapy. ,vol. 59, pp. 3899- 3905 ,(2015) , 10.1128/AAC.00861-15