The role of aberrant DNMT3Bs in tumor progression
作者：
DOI: 10.14800/CCM.847
关键词: Cancer epigenetics 、 DNA methylation 、 Carcinogenesis 、 Biology 、 Cancer cell 、 Cancer research 、 Epigenetics 、 Tumor progression 、 Cancer 、 DNMT3B 、 Bioinformatics
摘要: Cancer is among the most common causes of death in United States, second only to heart disease, and initiated by a loss cell cycle control resulting from deregulation oncogenes and/or tumor suppressor genes. Epigenetic changes, such as DNA methylation or histone modifications, are cancer cells leading altered gene regulation progression. Recently, studies have identified aberrant methyltransferase ( DNMT ) transcripts but not normal cells. Specifically, DNMT3B been shown role progression including ΔDNMT3B variants well DNMT3B7 . This review focuses on epigenetic changes caused s their suppression.
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