Epidemiology of AIDS dementia complex in Europe

摘要: The aim of the study was to describe epidemiology AIDS dementia complex (ADC) in Europe and assess possible role zidovudine therapy preventing or delaying its occurrence. We used an inception cohort, with data collected retrospectively from patients' clinical records 52 centers 17 countries across Europe. subjects were 6,548 adult people consecutively diagnosed 1979 1989. main outcome measures codiagnosis ADC at time diagnosis ADC-free after diagnosis. reported 295 patients (4.5%) during follow-up a further 402 5,160 (7.8%) who based on diseases other than ADC. Whether later, occurrence significantly associated age, transmission category, CD4+ cell counts. risk greater older (14 19% greater, after, respectively, for 5-year difference age), i.v. drug users homosexual bisexual men (89 60% respectively), lower counts 30% reduction 1 natural log scale). Risk almost double women men. A significant reduction, approximately 40%, found developing receiving therapy, but this effect present only first 18 months treatment, irrespective whether treatment began before In conclusion, increase either thereafter is increasing use, decreased count. Women tend have higher Zidovudine appears definite, time-limited, protecting against development