Effects of carvedilol therapy on QT-interval dispersion in congestive heart failure is there a difference in the elderly?

摘要: In cases of chronic congestive heart failure, QT-interval dispersion is a strong predictor death. Carvedilol therapy appears to decrease dispersion. We investigated whether carvedilol reduces in failure and this pharmaceutical agent has additional effects on elderly patients. Seventy-seven ambulatory patients who had were evaluated for hypertension, diabetes mellitus, smoking, alcohol abuse, concomitant medications, was then initiated. Six months later, we re-evaluated the same variables, as well morbidity mortality rates, number hospitalizations. The divided into 2 groups: Group I, aged or = 65 years (n 35). Statistics analyzed with Student's t-test chi2 test, Cox regression model. At 6 months, both groups showed significantly decreased values compared baseline (76.9 +/- 29.3 vs 104.3 41.5 ms, respectively; P 0.05). II smaller reduction than did I (24.41 29.36 30.98 32.70 respectively), but difference not significant. conclude that long-term decreases dispersion, effect uniformly distributed between < those 265 years.