Effects of valsartan and nebivolol on blood pressure, QT dispersion and left ventricular hypertrophy in hypertensive patients Hipertansif hastalarda valsartan ve nebivololun, kan basinci, QT dağilimi ve sol ventrikül hipertrofisi üzerine etkileri

摘要: Objectives: The aim of this study was to analyze the antihypertensive effect Valsartan and Nebivolol their effects on QT dispersion left ventricular hypertrophy (LVH) in treatment naive hypertensive patients. Methods: A prospective with a six-month follow-up conducted patients LVH mild/ moderate essential hypertension. were randomly assigned (80 160 mg/day) or (5 10 groups. group consisted 108 patients, 55 53 group. Results: range mean systolic blood pressure (SBP) varied from 152±17 (baseline) 132±17 mmHg (follow-up) (p<0.001); 146±13 125±14 (p<0.001). decrease diastolic (DBP) 9.5±2.5 12.3±5.0 significant reduction corrected (Bazett’s formula) observed both groups, slightly higher Echocardiography showed ventricle mass (LVM) indices (p<0.05) groups greater Conclusion: as effective reducing 24 hour- SBP after 6 month treatment. proved be superior DBP. Both therapies LVH; interval indexes relation LVM reduction.