Periodontal wound healing following GTR therapy of dehiscence-type defects in the monkey: short-, medium- and long-term healing.
作者： Filippo Graziani , Lars Laurell , Maurizio Tonetti , Jan Gottlow , Tord Berglundh
DOI: 10.1111/J.1600-051X.2005.00789.X
关键词: Orthodontics 、 Medicine 、 Periodontium 、 Dentistry 、 Dentin 、 Dehiscence 、 Mandibular second molar 、 Cementum 、 Root surface 、 Buccal administration 、 Wound healing
摘要: Objective: To describe periodontal wound healing in dehiscence-type defects following guided tissue re-generation (GTR) therapy. Methods: Ten adult Macaca fascicularis monkeys were used. Buccal created at the maxillary second pre-molars and molars. After 3 months, GTR surgery was performed. The animals euthanized 6 weeks, months 2 years after surgery. Block biopsies harvested, prepared for histological analysis. Results: A new attachment apparatus structured already weeks of healing. 10–20 μm thin layer acellular extrinsic fibre cementum (AEFC) had formed along instrumented root surface. At thickness supracrestal comparable with that while subcrestal increased to 40–60 μm. In this zone, consisted an inner AEFC attached circum–pulpal dentin outer cellular mixed (CMFC). numerical density twice weeks. years, tissues resembled pristine periodontium. Conclusion: Periodontal therapy recession-type will result a restitutio ad integrum, i.e. by re-generation. continuous maturation process occurs over least years.
hku.hk
sci-hub.se 参考文章(24)
M. Araujo, T. Berglundh, J. Lindhe, The periodontal tissues in healed degree III furcation defects. An experimental study in dogs. Journal of Clinical Periodontology. ,vol. 23, pp. 532- 541 ,(1996) , 10.1111/J.1600-051X.1996.TB01821.X
N. Donos, A. Sculean, L. Glavind, E. Reich, T. Karring, Wound healing of degree III furcation involvements following guided tissue regeneration and/or Emdogain. A histologic study. Journal of Clinical Periodontology. ,vol. 30, pp. 1061- 1068 ,(2003) , 10.1046/J.0303-6979.2003.00429.X
M. G. Araujo, T. Berglundh, J. Lindhe, ON THE DYNAMICS OF PERIODONTAL TISSUE FORMATION IN DEGREE III FURCATION DEFECTS AN EXPERIMENTAL STUDY IN DOGS Journal of Clinical Periodontology. ,vol. 24, pp. 738- 746 ,(1997) , 10.1111/J.1600-051X.1997.TB00191.X
Jan Gottlow, Sture Nyman, Thorkild Karring, Jan Lindhe, Treatment of localized gingival recessions with coronally displaced flaps and citric acid. An experimental study in the dog. Journal of Clinical Periodontology. ,vol. 13, pp. 57- 63 ,(1986) , 10.1111/J.1600-051X.1986.TB01415.X
A. Sculean, N. Donos, M. Brecx, T. Karring, E. Reich, Healing of fenestration-type defects following treatment with guided tissue regeneration or enamel matrix proteins Clinical Oral Investigations. ,vol. 4, pp. 50- 56 ,(2000) , 10.1007/S007840050113
Max A. Listgarten, Electron microscopic study of the junction between surgically denuded root surfaces and regenerated periodontal tissues Journal of Periodontal Research. ,vol. 7, pp. 68- 90 ,(1972) , 10.1111/J.1600-0765.1972.TB00633.X
M. G. Araujo, T. Berglundh, J. Lindhe, GTR treatment of degree III furcation defects with 2 different resorbable barriers An experimental study in dogs Journal of Clinical Periodontology. ,vol. 25, pp. 253- 259 ,(1998) , 10.1111/J.1600-051X.1998.TB02436.X
Jan Gottlow, Thorkild Karring, Sture Nyman, Guided Tissue Regeneration Following Treatment of Recession-Type Defects in the Monkey Journal of Periodontology. ,vol. 61, pp. 680- 685 ,(1990) , 10.1902/JOP.1990.61.11.680
P. Schupbach, T. Gaberthuel, F. Lutz, B. Guggenheim, Periodontal repair or regeneration: structures of different types of new attachment. Journal of Periodontal Research. ,vol. 28, pp. 281- 293 ,(1993) , 10.1111/J.1600-0765.1993.TB02095.X
Lars Hammarstrom, Lars Heijl, Stina Gestrelius, Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. Journal of Clinical Periodontology. ,vol. 24, pp. 669- 677 ,(1997) , 10.1111/J.1600-051X.1997.TB00248.X