Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

摘要: Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes NADPH-dependent condensation acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription FAS gene controlled synergistically by transcription factors ChREBP (carbohydrate response element-binding protein), which induced glucose, SREBP-1 (sterol protein-1), stimulated insulin through PI3K/Akt signal transduction pathway. We investigated whether genetic variability genes encoding for ChREBP, SREBP (respectively, MLXIPL, SREBF1 FASN) related breast cancer risk body-mass index (BMI) studying 1,294 cases 2,452 controls from European Prospective Investigation on Cancer (EPIC). resequenced combined information SNPs found resequencing public databases. Using a tagging approach selecting 20 SNPs, we covered all common variation these genes. In this study were not able find any statistically significant association between in FAS, SREPB-1 an increased overall subgroups age, menopausal status, hormone replacement therapy (HRT) use or BMI. On other hand, that two FASN associated with