T cell receptor excision circles and HIV-1 2-LTR episomal DNA to predict AIDS in patients not receiving effective therapy.

摘要: Objective: To determine whether improved prediction of AIDS-free survival following HIV-1 seroconversion is achieved by measuring 2-LTR episomal DNA (2-LTR) circles and T cell receptor rearrangement excision (TREC), reflecting HIV replication lymphocyte emigration from the thymus, respectively. Design: Subanalysis a cohort 154 patients with hemophilia who became positive between 1978 1985 were followed prospectively. Methods: Relative hazards (RH) AIDS, in absence highly effective anti-HIV therapy, estimated for age, viral load, CD4 count levels TREC [per 10 6 peripheral blood mononuclear cells (PBMC)]. Results: correlated significantly counts (r = 0.30) age -0.60). load 0.35). If lymphocytes included proportional model, risk AIDS during median 11.6 years follow-up was increased fewer (adjusted RH, 2.0 per log copies/10 PBMC) more (RH, 1.7 PBMC). held most subgroups defined age. Conclusions: PBMC that have high low recent thymic emigrants are associated substantially AIDS. It not known if measurement either or will complement as an estimation receiving therapy.