作者: Ankur vaidya , Aviral Jain , Piush Khare , Ram K. Agrawal , Sanjay K. Jain
DOI: 10.1002/JPS.21742
关键词: Microparticle 、 Drug 、 Pectin 、 Absorption (skin) 、 Pharmacology 、 In vitro 、 In vivo 、 Chromatography 、 Route of administration 、 Chemistry 、 Pharmacokinetics
摘要: A multiparticulate system having pH-sensitive property and specific enzyme biodegradability for colon-targeted delivery of metronidazole was developed. Pectin microspheres were prepared using emulsion-dehydration technique. These coated with Eudragit® S-100 oil-in-oil solvent evaporation method. The SEM used to characterize the surface these a distinct coating over could be seen. in vitro drug release studies exhibited no at gastric pH, however continuous observed from formulation colonic pH. Further, found higher presence rat caecal contents, indicating effect enzymes on pectin microspheres. vivo also performed by assessing concentration various parts GIT different time intervals which potentiality colon targeting. Hence, it can concluded that Eudragit drug. © 2009 Wiley-Liss, Inc. American Pharmacists Association J Pharm Sci 98:4229–4236,