Metronidazole loaded pectin microspheres for colon targeting

作者: Ankur vaidya , Aviral Jain , Piush Khare , Ram K. Agrawal , Sanjay K. Jain

DOI: 10.1002/JPS.21742

关键词: MicroparticleDrugPectinAbsorption (skin)PharmacologyIn vitroIn vivoChromatographyRoute of administrationChemistryPharmacokinetics

摘要: A multiparticulate system having pH-sensitive property and specific enzyme biodegradability for colon-targeted delivery of metronidazole was developed. Pectin microspheres were prepared using emulsion-dehydration technique. These coated with Eudragit® S-100 oil-in-oil solvent evaporation method. The SEM used to characterize the surface these a distinct coating over could be seen. in vitro drug release studies exhibited no at gastric pH, however continuous observed from formulation colonic pH. Further, found higher presence rat caecal contents, indicating effect enzymes on pectin microspheres. vivo also performed by assessing concentration various parts GIT different time intervals which potentiality colon targeting. Hence, it can concluded that Eudragit drug. © 2009 Wiley-Liss, Inc. American Pharmacists Association J Pharm Sci 98:4229–4236,

参考文章(21)
Abraham Rubinstein, Raphael Radai, Miriam Ezra, Seema Pathak, J. Stefan Rokem, In Vitro Evaluation of Calcium Pectinate: A Potential Colon-Specific Drug Delivery Carrier Pharmaceutical Research. ,vol. 10, pp. 258- 263 ,(1993) , 10.1023/A:1018995029167
Guy Van den Mooter, Celest Samyn, Renaat Kinget, The relation between swelling properties and enzymatic degradation of azo polymers designed for colon-specific drug delivery. Pharmaceutical Research. ,vol. 11, pp. 1737- 1741 ,(1994) , 10.1023/A:1018911316021
M K Chourasia, S K Jain, Pharmaceutical approaches to colon targeted drug delivery systems. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences. ,vol. 6, pp. 33- 66 ,(2003)
Etienne Schacht, An Gevaert, El Refaie Kenawy, Koen Molly, Willy Verstraete, Peter Adriaensens, Robert Carleer, Jan Gelan, Polymers for colon specific drug delivery. Journal of Controlled Release. ,vol. 39, pp. 327- 338 ,(1996) , 10.1016/0168-3659(95)00184-0
Norihito Shimono, Toshihito Takatori, Masumi Ueda, Masaaki Mori, Yutaka Higashi, Yasuhiko Nakamura, Chitosan Dispersed System for Colon-specific Drug Delivery International Journal of Pharmaceutics. ,vol. 245, pp. 45- 54 ,(2002) , 10.1016/S0378-5173(02)00344-7
Amol Paharia, Awesh K Yadav, Gopal Rai, Sunil K Jain, Shyam S Pancholi, Govind P Agrawal, None, Eudragit-coated pectin microspheres of 5-fluorouracil for colon targeting. Aaps Pharmscitech. ,vol. 8, pp. 12- 12 ,(2007) , 10.1208/PT0801012
M. K. Chourasia, S. K. Jain, Design and Development of Multiparticulate System for Targeted Drug Delivery to Colon Drug Delivery. ,vol. 11, pp. 201- 207 ,(2004) , 10.1080/10717540490445955
M.L Lorenzo-Lamosa, C Remuñán-López, J.L Vila-Jato, M.J Alonso, Design of microencapsulated chitosan microspheres for colonic drug delivery. Journal of Controlled Release. ,vol. 52, pp. 109- 118 ,(1998) , 10.1016/S0168-3659(97)00203-4
Soodabeh Davaran, Jalal Hanaee, Abbas Khosravi, Release of 5-amino salicylic acid from acrylic type polymeric prodrugs designed for colon-specific drug delivery Journal of Controlled Release. ,vol. 58, pp. 279- 287 ,(1999) , 10.1016/S0168-3659(98)00167-9