Biosynthesis and cytokinin activity of 8-hydroxy and 2,8-dihydroxy derivatives of zeatin and N-6(increment-2-isopentenyl)adenine.
作者： Chong-Maw Chen , O'Brien C. Smith , James D. McChesney
DOI: 10.1021/BI00685A008
关键词: Purine 、 Zeatin 、 Xanthine oxidase 、 Cytokinin 、 Bioassay 、 Stereochemistry 、 Biochemistry 、 Biosynthesis 、 Chemistry
摘要: 8-Hydroxy and 2,8-dihydroxy derivatives of the cytokinins, 6-(4-hydroxy-3-methyl-trans-2-butenylamino)purine N-6-(increment -2-isopentenyl)adenine, have been biosynthesized by xanthine oxidase oxidation. shown to be major intermdeiates. These compounds were tested for cytokinin activity in tobacco bioassay. The results suggest that substitution 8 position with a hydroxyl group causes less decrease than both 2 positions groups.
sci-hub.se 参考文章(38)
Bruce Mackler, H.R. Mahler, D.E. Green, Studies on metalloflavoproteins. I. Xanthine oxidase, a molybdoflavoprotein. Journal of Biological Chemistry. ,vol. 210, pp. 149- 164 ,(1954) , 10.1016/S0021-9258(18)65441-9
Irwin Fridovich, Philip Handler, Xanthine oxidase. III. Sulfite oxidation as an ultra sensitive assay. Journal of Biological Chemistry. ,vol. 233, pp. 1578- 1580 ,(1958) , 10.1016/S0021-9258(18)49375-1
Ross H. Hall, N6-(δ2-Isopentenyl)adenosine: Chemical Reactions, Biosynthesis, Metabolism, and Significance to the Structure and Function of †RNA Progress in Nucleic Acid Research and Molecular Biology. ,vol. 10, pp. 57- 86 ,(1970) , 10.1016/S0079-6603(08)60561-9
Malcolm B. Wilkins, The physiology of plant growth and development ,(1969)
Aaron. Bendich, George.Bosworth. Brown, Frederick S. Philips, J.B. Thiersch, THE DIRECT OXIDATION OF ADENINE IN VIVO Journal of Biological Chemistry. ,vol. 183, pp. 267- 277 ,(1950) , 10.1016/S0021-9258(18)56464-4
Laurence G. Dammann, Nelson J. Leonard, Ruth Y.Schmitz, Folke Skoog, Cytokinins: Synthesis of 2-, 8-, and 2,8-substituted 6-(3-methyl-2-butenylamino)purines and their relative activities in promoting cell growth Phytochemistry. ,vol. 13, pp. 329- 336 ,(1974) , 10.1016/S0031-9422(00)91213-5
Chung Il Hong, Girish B. Chheda, Shib P. Dutta, Anne O'Grady-Curtis, George L. Tritsch, Synthesis and biological activity of analogs of naturally occurring 6-ureidopurines and their nucleosides. Journal of Medicinal Chemistry. ,vol. 16, pp. 139- 147 ,(1973) , 10.1021/JM00260A013
Thomas R. Henderson, Charles G. Skinner, Robert E. Eakin, Kinetin & Kinetin Analogues as Substrates & Inhibitors of Xanthine Oxidase Plant Physiology. ,vol. 37, pp. 552- 555 ,(1962) , 10.1104/PP.37.4.552
Chong-Maw Chen, Gary F. Hartnell, O'Brien C. Smith, Walter S. Francis, Quantitative measurement of hypermodified adenosine ribonucleosides in plant tissues Analytical Biochemistry. ,vol. 60, pp. 441- 448 ,(1974) , 10.1016/0003-2697(74)90253-X
J. Eugene Fox, Growth Factor Requirements and Chromosome Number in Tobacco Tissue Cultures Physiologia Plantarum. ,vol. 16, pp. 793- 803 ,(1963) , 10.1111/J.1399-3054.1963.TB08356.X