The Role of Toll-Like Receptors in Retroviral Infection.

摘要: Toll-like receptors (TLRs) are key pathogen sensing that respond to diverse microbial ligands, and trigger both innate adaptive immune responses infection. Since their discovery, a growing body of evidence has pointed an important role for TLRs in retroviral infection pathogenesis. These data suggest multiple contribute the anti-retroviral response, TLR engagement by retroviruses can have complex divergent outcomes Despite this progress, numerous questions remain about In review, I summarize existing TLR-retrovirus interactions functional roles these play immunity pathogenesis, with particular focus on human immunodeficiency virus (HIV).