Serum non-transferrin-bound iron and low-density lipoprotein oxidation in heterozygous hemochromatosis
作者： Lambertus J.H. van Tits , Esther M.G. Jacobs , Dorine W. Swinkels , Heidi L.M. Lemmers , Gerly M. van der Vleuten
DOI: 10.1016/J.BBRC.2006.04.100
关键词: Hemochromatosis 、 Hereditary hemochromatosis 、 Biochemistry 、 Low-density lipoprotein 、 Lipoprotein 、 Endocrinology 、 Transferrin 、 Apolipoprotein B 、 In vivo 、 Internal medicine 、 Chemistry 、 Lipid peroxidation
摘要: Non-transferrin-bound iron (NTBI) is implicated in lipid peroxidation but the relation with oxidative modification of low-density lipoprotein (LDL) not known. We assessed variables reflecting vitro and vivo LDL oxidation two age- sex-matched groups (n = 23) hereditary hemochromatosis heterozygotes (C282Y), characterized by a clear difference mean serum NTBI (1.55 ± 0.57 μmol/L vs 3.70 0.96 μmol/L). Plasma level oxidized (absolute relative to plasma apolipoprotein B), IgG IgM antibodies LDL, markers oxidation, did differ between low high NTBI. Mean lag-phase was also significantly different both study groups. Conclusion: these findings do support hypothesis that promotes LDL.
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