Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
作者： Alison M. Lawrie , Martin E.M. Noble , Paul Tunnah , Nicholas R. Brown , Louise N. Johnson
DOI: 10.1038/NSB1097-796
关键词: Cell biology 、 Protein kinase A 、 Cyclin-dependent kinase 2 、 Staurosporine 、 Cyclin-dependent kinase 、 Kinase 、 Biology 、 Mitogen-activated protein kinase kinase 、 Protein structure 、 c-Raf
摘要: Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure CDK2 staurosporine complex explains the tight binding this inhibitor, and suggests features to be exploited in design specific inhibitors CDKs.
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