Iron Acquisition and Microbial Virulence: Potential Uptake Systems in the Aeromonas Species

作者: B. R. Byers , J. E. L. Arceneaux , S. Barghouthi , G. Massad , S. Zywno

DOI: 10.1007/978-1-4615-3810-3_30

关键词: MicrobiologyIron acquisitionHost (biology)Aeromonas speciesBacteriaHeme ironVirulenceBiologyIron uptake

摘要: Colonization of an animal host by a disease causing bacterial species involves complex sequence events that includes entry and multiplication, sometimes with damage to the host.1 At each step has placed barricades initiate various vs. microbe conflicts on which outcome invasion is balanced. Competition for iron key biofulcrum.2 The winner battle may not ultimately win war but absolute nutritional requirement bacteria means will never without capturing metal from its host. Identifying retention gathering weapons used two competitors constitutes fascinating, still incomplete, study. techniques modern molecular biology enable more precise determination related virulence molecules genes encoding their synthesis. While some general acquisition modes are evident, tactics employed different have be defined case-by-case basis. With detailed knowledge systems, it possible devise enhancing host’s withholding defenses.

参考文章(27)
J Alam, A Smith, Receptor-mediated transport of heme by hemopexin regulates gene expression in mammalian cells. Journal of Biological Chemistry. ,vol. 264, pp. 17637- 17640 ,(1989) , 10.1016/S0021-9258(19)84616-1
Medoff G. y Eisenstein B. Schaechter M, Mechanisms of Microbial Disease ,(1993)
S Barghouthi, R Young, M O Olson, J E Arceneaux, L W Clem, B R Byers, Amonabactin, a novel tryptophan- or phenylalanine-containing phenolate siderophore in Aeromonas hydrophila. Journal of Bacteriology. ,vol. 171, pp. 1811- 1816 ,(1989) , 10.1128/JB.171.4.1811-1816.1989
N H Carbonetti, S Boonchai, S H Parry, V Väisänen-Rhen, T K Korhonen, P H Williams, Aerobactin-mediated iron uptake by Escherichia coli isolates from human extraintestinal infections. Infection and Immunity. ,vol. 51, pp. 966- 968 ,(1986) , 10.1128/IAI.51.3.966-968.1986
C Simonson, D Brener, I W DeVoe, Expression of a high-affinity mechanism for acquisition of transferrin iron by Neisseria meningitidis. Infection and Immunity. ,vol. 36, pp. 107- 113 ,(1982) , 10.1128/IAI.36.1.107-113.1982
P Brandt, Mahoney, J. Lee, J. Eaton, Haptoglobin: a natural bacteriostat Science. ,vol. 215, pp. 691- 693 ,(1982) , 10.1126/SCIENCE.7036344
S. Peter Howard, J. Thomas Buckley, Molecular cloning and expression in Escherichia coli of the structural gene for the hemolytic toxin aerolysin from Aeromonas hydrophila. Molecular Genetics and Genomics. ,vol. 204, pp. 289- 295 ,(1986) , 10.1007/BF00425512
S. Barghouthi, R. Young, J. E. L. Arceneaux, B. R. Byers, Physiological control of amonabactin biosynthesis inAeromonas hydrophila Biology of Metals. ,vol. 2, pp. 155- 160 ,(1989) , 10.1007/BF01142554
Ralph T. Francis, Joseph W. Booth, Robert R. Becker, Uptake of iron from hemoglobin and the haptoglobin-hemoglobin complex by hemolytic bacteria. International Journal of Biochemistry. ,vol. 17, pp. 767- 773 ,(1985) , 10.1016/0020-711X(85)90262-9