Synchronous multiple primary gastrointestinal cancer exhibits frequent microsatellite instability.
作者： Hiroshi Ohtani , Masakazu Yashiro , Naoyoshi Onoda , Nobuaki Nishioka , Yasuyuki Kato
DOI: 10.1002/(SICI)1097-0215(20000601)86:5<678::AID-IJC12>3.0.CO;2-O
关键词: Gastrointestinal cancer 、 Colorectal cancer 、 Pathology 、 Frameshift mutation 、 Mutation 、 Microsatellite instability 、 Carcinogenesis 、 Loss of heterozygosity 、 Biology 、 Cancer research 、 Bcl-2-associated X protein
摘要: Colorectal (CRC) and gastric cancers (GC), the most common gastrointestinal malignancies, have been known to develop occasionally in a same patient. Previous studies focused on etiology of patients with multiple primary colorectal cancer (MPGCC); however, carcinogenic process MPGCC remains unclear. In this study, we examined genetic alterations order clarify pathway. Twenty sporadic were for microsatellite instability (MSI) frameshift mutations target genes such as TGFbetaRII, BAX IGFIIR. 10 (50%) 20 MPGCC, MSI was present at least 1 lesion GC or CRC. Four 8 cases synchronous displayed both CRC, while only (8%) 12 metachronous exhibited organs. Carcinogenic fairly associated pathway, particularly MPGCC. found 5 (25%) GCs CRCs. involved more closely CRC than among Although MSI-positive infrequent observed genes. Frameshift mutation TGFbetaRII. Only 2 showed case also Our findings suggest that IGFIIR are not main carcinogenesis
sci-hub.se 参考文章(18)
Richard Fishel, Mary Kay Lescoe, M.R.S. Rao, Neal G. Copeland, Nancy A. Jenkins, Judy Garber, Michael Kane, Richard Kolodner, The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer Cell. ,vol. 75, pp. 1027- 1038 ,(1993) , 10.1016/0092-8674(93)90546-3
Michael F. Lyons, John Redmond, Henry Covelli, Multiple primary neoplasia of the head and neck and lung. The changing histopathology. Cancer. ,vol. 57, pp. 2193- 2197 ,(1986) , 10.1002/1097-0142(19860601)57:11<2193::AID-CNCR2820571119>3.0.CO;2-M
Lauri A Aaltonen, Päivi Peltomäki, Fredrick S Leach, Pertti Sistonen, Lea Pylkkänen, Jukka-Pekka Mecklin, Heikki Järvinen, Steven M Powell, Jin Jen, Stanley R Hamilton, Gloria M Petersen, Kenneth W Kinzler, Bert Vogelstein, Albert De La Chapelle, Clues to the pathogenesis of familial colorectal cancer Science. ,vol. 260, pp. 812- 816 ,(1993) , 10.1126/SCIENCE.8484121
T. Toda, M. Segawa, Y. Nomura, I. Nonaka, K. Masuda, T. Ishihara, M. Suzuki, I. Tomita, Y. Origuchi, K. Ohno, N. Misugi, Y. Sasaki, K. Takada, M. Kawai, K. Otani, T. Murakami, K. Saito, Y. Fukuyama, T. Shimizu, I. Kanazawa, Y. Nakamura, Localization of a gene for Fukuyama type congenital muscular dystrophy to chromosome 9q31-33 Nature Genetics. ,vol. 5, pp. 283- 286 ,(1993) , 10.1038/NG1193-283
Rhonda F. Souza, Rebecca Appel, Jing Yin, Suna Wang, Kara N. Smolinski, John M. Abraham, Tong-Tong Zou, Ying-Qiang Shi, Junyi Lei, John Cottrell, Karina Cymes, Kelli Biden, Lisa Simms, Barbara Leggett, Patrick M. Lynch, Marsha Frazier, Steven M. Powell, Noam Harpas, Hirohasi Sugimura, Joanne Young, Stephen J. Meltzer, Microsatellite instability in the insulin–like growth factor II receptor gene in gastrointestinal tumours Nature Genetics. ,vol. 14, pp. 255- 257 ,(1996) , 10.1038/NG1196-255
Nicholas Rampino, Hiroyuki Yamamoto, Yurij Ionov, Yan Li, Hisako Sawai, John C. Reed, Manuel Perucho, Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science. ,vol. 275, pp. 967- 969 ,(1997) , 10.1126/SCIENCE.275.5302.967
S Markowitz, J Wang, L Myeroff, R Parsons, L Sun, J Lutterbaugh, R. Fan, E Zborowska, K. Kinzler, B Vogelstein, al. et, Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability Science. ,vol. 268, pp. 1336- 1338 ,(1995) , 10.1126/SCIENCE.7761852
Monica Pedroni, Maria Grazia Tamassia, Antonio Percesepe, Luca Roncucci, Piero Benatti, Giovanni Lanza, Roberta Gaf�, Carmela Di Gregorio, Rossella Fante, Lorena Losi, Luca Gallinari, Francesca Scorcioni, Fabiana Vaccina, Giuseppina Rossi, Anna Maria Cesinaro, Maurizio Ponz de Leon, Microsatellite instability in multiple colorectal tumors. International Journal of Cancer. ,vol. 81, pp. 1- 5 ,(1999) , 10.1002/(SICI)1097-0215(19990331)81:1<1::AID-IJC1>3.0.CO;2-K
Minna Nyström-Lahti, Raquel Seruca, Ragnhild A. Lothe, Lauri A. Aaltonen, Aage Haugen, David Ryberg, Ruth Holm, Anton Brøgger, Leonor David, Päivi Peltomäki, Albert de la Chapelle, Anne-Lise Børresen, Lea Pylkkänen, Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. Cancer Research. ,vol. 53, pp. 5853- 5855 ,(1993)
Akio Yanagisawa, Eiichi Tahara, Wataru Yasui, Hye-Jung Han, Yo Kato, Hirotoshi Ohta, Mamoru Shimada, Akira Horii, Yusuke Nakamura, Frequent Replication Errors at Microsatellite Loci in Tumors of Patients with Multiple Primary Cancers Cancer Research. ,vol. 54, pp. 3373- 3375 ,(1994)