Scaling of brain compartments to brain size.

摘要: In this study, we examine the relationship between total brain volume (BV) and volumes of several main compartmental (BC) measures (cortical thickness, cortical surface area, corpus callosum, gray matter, normal appearing cerebral white matter (NAWM), amygdala, accumbens, caudate, hippocampus, putamen, pallidum, thalamus, cerebellar WM) physically cognitively healthy elderly individuals (mean age: 71 years, age range: 65-85 years). The statistical analysis uncovered extremely different relationships BV aforementioned BC metrics. These ranged from strong (BV explaining 85% variability WM volume) to a very small (for caudate thickness). addition, accumbens scaled out proportion with BV, whereas most other less than proportional BV. Thus, larger brains exhibit relatively NAWM do smaller brains. Cortical (and measures), on hand, decreases as increases, resulting in measures) for large are discussed within context general allometric scaling principles human brain. possible methodological consequences analyzing anatomical data basis MRI measurements also discussed.