Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses
作者： Stuart L Johnson , Christoph Franz , Stephanie Kuhn , David N Furness , Lukas Rüttiger
DOI: 10.1038/NN.2456
关键词: Hair cell 、 Vesicle fusion 、 SNAP25 、 Neuroscience 、 Ribbon synapse 、 Cell biology 、 Synaptic vesicle 、 Exocytosis 、 Synaptotagmin I 、 Biology 、 Synaptotagmins
摘要: Mammalian cochlear inner hair cells (IHCs) are specialized for the dynamic coding of continuous and finely graded sound signals. This ability is largely conferred by linear Ca2+ dependence neurotransmitter release at their synapses, which also a feature visual olfactory systems. The prevailing hypothesis that linearity in IHCs occurs through developmental change sensitivity synaptic vesicle fusion from nonlinear (high order) immature spiking cells. However, nature sensor(s) cell synapses unknown. We found synaptotagmin IV was essential establishing exocytotic adult rodent outer Moreover, expression hitherto undetected synaptotagmins I II correlated with high-order IHCs. propose differential determines characteristic synapses.
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