A retrospective study of NENs and miR-224 promotes apoptosis of BON-1 cells by targeting PCSK9 inhibition.

摘要: // Jian’an Bai 1 , He Na 2 Xiumei Hua Yaling Wei Tian Ye Yiqiang Zhang 3 Guo Jian 4 Weiwen Zeng Lijun Yan Qiyun Tang Department of Gastroenterology, Sir Run Hospital Affiliated with Nanjing Medical University, Nanjing, China The First Radiology, Linyi People's Hospital, Dezhou, Orthopaedics, People’s Correspondence to: Tang, email: tqy831@163.com Keywords: NENs, epidemiology, LDL-C, PCSK9, miR-224 Received: February 29, 2016      Accepted: December 16, Published: 28, 2016 ABSTRACT Neuroendocrine neoplasms (NENs) represent relatively rare tumors. lack diagnostic, therapeutic method and prognostic factors makes them a challenge to us. We retrospectively reviewed the data 205 NENs patients among which 157 cases were followed-up. Proprotein convertase subtilisin/kexin 9 (PCSK9), regulator low density lipoprotein cholesterol (LDL-C), was confirmed as target gene microRNA-224. found an increased incidence from 2012 2015. Women usually diagnosed at earlier stages than men ( P < 0.05). Tumor grading associated primary tumor site, especially esophagus cardia all G3 <0.001). Age, LDL-C levels independent risk digestive NENs. Low level significantly correlated survival rate median overall (OS, MicroRNA-224 agomir PCSK9 siRNA could promote apoptosis suppress proliferation, invasion BON-1 cells 0.05), but increase glucocorticoid (GC, Taken together, age, are miR-224/PCSK9/GC axis binds tumorigenesis prognosis pancreatic (p-NENs).