Detecting white matter injury in sickle cell disease using voxel-based morphometry.
作者： Torsten Baldeweg , Alexandra M. Hogan , Dawn E. Saunders , Paul Telfer , David G. Gadian
DOI: 10.1002/ANA.20790
关键词: Voxel-based morphometry 、 Cerebral infarction 、 Magnetic resonance imaging 、 Pathology 、 White matter 、 Voxel 、 Sickle cell anemia 、 Population 、 Infarction 、 Medicine
摘要: Objective: Sickle cell disease (SCD) is associated with cerebrovascular disease, cerebral infarction, and cognitive dysfunction. This study aimed to detect the presence extent of white matter abnormalities in individuals SCD using voxel-based morphometry (VBM). Methods: Thirty-six children adolescents (age range, 9-24 years) 31 controls (8-25 underwent magnetic resonance investigations T1- T2-weighted protocols. White gray density maps were obtained from three-dimensional imaging (MRI) data sets. Using VBM, we compared between silent infarct lesions (SCD+L; n = 16), those without visible abnormality (SCD-L; 20). Results: In comparison controls, intelligence quotients (IQs) lower both groups irrespective lesions. VBM showed widespread bilateral SCD+L group, extending beyond regions focal infarction deep anterior posterior borderzones. Bilateral also observed SCD-L locations similar group. Interpretation: sensitive detection injury patients borderzones arterial territories even absence evidence infarction. Those changes may contribute deficits this population.
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