The impact of prenatal stress on basal nociception and evoked responses to tail-docking and inflammatory challenge in juvenile pigs.

摘要: The consequences of tail-docking (at 2–4 days) and prenatal stress (maternal social during the 2nd third pregnancy) on baseline nociceptive thresholds responses to acute inflammatory challenge were investigated in juvenile pigs two studies. Nociceptive assessed tail root hind foot using noxious mechanical cold stimulation before after by intradermal injection 30 μg capsaicin (study 1) or 3% carrageenan 2) into root. Four groups 8 1, n = 14–16 pigs/treatment) 5 2, 6 pigs/treatment/sex) week-old exposed main factors: maternal treatment (docked vs. intact tails). In study docking did not significantly alter stimulation, whilst prenatally stressed had higher than unstressed pigs, whether tail-docked intact. Capsaicin induced localised allodynia around all groups, but no effect plantar responses; however offspring exhibited attenuated response compared controls. 2 either stimulation. Baseline durations shorter both sexes male female controls, although results tended towards significance. Carrageenan effects that pigs. Collectively, these findings indicate can induce long-term alterations responses, manifest as a reduced sensitivity evoked allodynia. Neonatal does lead nociception