5‐(4‐Nitrophenyl)‐1H‐tetrazole
作者： Qingwei Yao
DOI: 10.1002/047084289X.RN00278
关键词: Ammonium chloride 、 Anhydrous 、 Zinc bromide 、 Sodium azide 、 Desiccator 、 Reagent 、 Organic chemistry 、 Solubility 、 Chemistry 、 Solvent
摘要: [16687-60-8] C7H5N5O2 (MW 191.15) InChI = 1S/C7H5N5O2/c13-12(14)6-3-1-5(2-4-6)7-8-10-11-9-7/h1-4H,(H,8,9,10,11) InChIKey = MIUOBAHGBPSRKY-UHFFFAOYSA-N (reagent used as activator for both solution- and solid-phase synthesis of oligonucleotides using the phosphoramidite method) Physical Data: mp 225–226 °C. Solubility: insoluble in H2O; soluble DMSO; this reagent is only slightly most commonly solvent oligonucleotide synthesis, i.e., acetonitrile (<0.12 M),3 but more THF (up to 0.8 M).4 Form Supplied in: white or colored powder; commercially available. Analysis Reagent Purity: the may be checked by mp analyzed standard techniques. Preparative Methods: the can readily prepared from 4-nitrobenzonitrile sodium azide presence ammonium chloride anhydrous DMF.1 It also reaction water zinc bromide catalyst.2 Purification: recrystallization either ethanol, isopropanol, ethanol/water. Handling, Storage, Precautions: this should handled with caution. irritating eyes respiratory system, harmful skin. Avoid contact strong heat metal salts, since tetrazoles explosive. stored dark a desiccator.
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