Solid phase synthesis of the 3′-terminal nonadecaribonucleoside octadecaphosphate sequence of yeast alanine transfer ribonucleic acid

作者: T.Sudhakar Rao , Colin B. Reese , Halina T. Serafinowska , Hiroshi Takaku , Giovanni Zappia

DOI: 10.1016/S0040-4039(00)96655-3

关键词: StereochemistryOrganic chemistrySolid-phase synthesisSequence (biology)PhosphoramiditeTransfer RNAChemistryOligoribonucleotidesAlanineControlled pore glassYeast

摘要: Abstract The rapid synthesis of the 3′-terminal decaribonucleoside nonaphosphate and nonadecaribonucleoside octadecaphosphate sequences yeast tRNA Ala by phosphoramidite approach on controlled pore glass is described; synthetic products were found to be identical authentic oligoribonucleotides, prepared phosphotriester in solution.

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