Incompatibility of acid-labile 2′ and 5′ protecting groups for solid-phase synthesis of oligoribonucleotides
作者： Chris Christodoulou , Sudhir Agrawal , Michael J. Gait
DOI: 10.1016/S0040-4039(00)84302-6
关键词: Ribonucleoside 、 Oligoribonucleotides 、 Acid labile 、 Stereochemistry 、 Cleavage (embryo) 、 Chemistry 、 Organic chemistry 、 Solid-phase synthesis
摘要: Abstract Cleavage of 2−O-tetrahydropyranyl groups from ribonucleoside derivatives used in solid-phase oligoribonucleotide synthesis takes place to an unacceptable extent during treatment with protic acid remove 5′-O-pixyl groups.
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