Structure of the hamster low density lipoprotein receptor gene.
作者： RW Bishop
DOI: 10.1016/S0022-2275(20)41620-7
关键词: 5-HT5A receptor 、 Hamster 、 Biology 、 LDL receptor 、 Intron 、 Molecular biology 、 Gene 、 Exon 、 LRP1B 、 Low-density lipoprotein
摘要: The metabolism of low density lipoprotein (LDL) in the hamster is substantially similar to that human. To extend usefulness as an experimental model, LDL receptor gene was isolated and characterized. composed 18 exons 17 in- trons which span 26 kilobases. introns occur at precisely same positions those previously determined for human gene. predict protein 854 amino acids organization sequence predicted from cDNAs rat, rabbit, cow, Within 5'-flanking region are three highly conserved imperfect direct repeat se- quences 16 nucleotides each have been demonstrated regulate transcription. In addi- tion, a arrangement sequences also rat using polymerase chain reaction. These results indicate strong structural con- servation among several species further support model study LDkholesterol metabolism.-Bishop, R. W. Structure J. Lipid Res. 1992.33: 549-557.
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