Putative paraneoplastic pemphigus and myasthenia gravis in a cat with a lymphocytic thymoma

摘要: BACKGROUND Paraneoplastic pemphigus (PNP) is a rare and severe autoimmune blistering skin disease of humans. It associated mainly with haematopoietic neoplasia unique autoantibody profile. At this time in animals, PNP has only been reported dogs. OBJECTIVES To report clinical, histological immunological findings cat suspected thymoma-associated PNP. ANIMAL An 8-year-old female spayed Himalayan cat. RESULTS The presented thoracic mass diagnosed as lymphocytic thymoma. Two weeks postremoval, the developed myasthenia gravis, which was controlled prednisolone pyridostigmine. gravis resolved, but cutaneous erosions ulcers primarily affecting caudal ventral abdomen perineum, also chest, axillae medial pinnae. Histopathological analysis revealed changes consistent vulgaris erythema multiforme, combination lesions highly suggestive Direct immunofluorescence intercellular epidermal IgG deposition lower epidermis, especially areas suprabasal clefts. Indirect antikeratinocyte to basal keratinocytes bladder epithelial cells. Immunological results supported diagnosis Skin were treated chlorambucil and, after clinical remission obtained, drugs tapered eventually discontinued without further recurrence lesions. CONCLUSIONS AND CLINICAL IMPORTANCE In cat, microscopic PNP, thymoma being cause.