Evaluation of coexisting polymyositis in feline myasthenia gravis: a case series

摘要: Acquired myasthenia gravis (MG) is relatively uncommon in cats. In humans, MG may be associated with other immune-mediated disorders, particular polymyositis (PM). this study, we described in-depth electrodiagnostic findings and pathological changes muscles of cats diagnosed MG, assessed the presence concurrent PM. Six confirmed acetylcholine receptor antibody seropositive two suspected cases clinical signs electrophysiological consistent were reviewed. All animals presented severe typical generalized weakness and/or fatigability, resembling late-onset addition to regurgitation. Five a cranial mediastinal mass, 3 as thymoma. Repetitive nerve stimulation revealed decrement compound muscle action potential all tested cases, starting from low frequencies stimulation. Serum creatine kinase activity was increased 6/8 Muscle biopsies performed 5 varying degrees mixed mononuclear cell infiltrates, positive for leukocyte markers CD3/CD4/CD8 CD11b. Further MHC-1/C5b-9 sarcolemmal deposits identified or without This study documents an association PM cats, provides further support feline relevant animal model human MG.