Vaccine Therapy for Breast and Ovarian Cancers

摘要: Breast and ovarian cancers are ideal cancer vaccine targets for several reasons. Though perhaps not as immunogenic or responsive to immunotherapies melanoma renal cell carcinoma, evidence of endogenous immune responses exists in many patients with breast cancer. A number shared antigens potential also exist between these two malignancies. Both tissue tumor-associated known and, both organs dispensable, breaking self-tolerance tissue-specific is feasible. Additionally, adjuvant treatment early-stage disease common. Since it unlikely that vaccines will eradicate large tumor burdens, vaccination low burden probably be most beneficial. Patients often treated the setting when they have no measurable disease. Ovarian typically aggressively after presentation can rendered disease-free minimal groups a significant fairly predictable rate relapse. tend younger, healthier, less immunocompromised by their therapies than other patients. These diseases affect numbers remains second leading cause deaths American women, whereas epithelial ranks fifth (1). For reasons, excellent development readily available patient populations testing new approaches.