Isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels, glucose-6-phosphate dehydrogenase and glutathione reductase activities.
作者： Benedito Barraviera , Paulo Câmara Marques Pereira , Jussara Marcondes Machado , Maria Julia de Souza , Carlos Roberto G. Lima
DOI: 10.1590/S0037-86821991000200008
关键词: Blood sampling 、 Vitamin 、 Isoniazid 、 Internal medicine 、 Dehydrogenase 、 Biology 、 Immunology 、 Glutathione reductase 、 Endocrinology 、 Hematocrit 、 Glucose-6-phosphate dehydrogenase 、 Riboflavin
摘要: The authors evaluated the isoniazid acetylating phenotype and measured hematocrit, hemoglobin, glucose-6-phosphate dehydrogenase glutathione reductase activities plus serum sulfadoxin levels in 39 patients with paracoccidioidomycosis (33 males 6 females) aged 17 to 58 years. Twenty one (53.84%) of presented a slow acetylatingphenotype 18(46.16%) fast phenotype. Glucose-6-phosphate- (G6PD) acti vity was decreased 5(23.80%) acetylators 4(22.22%) acetylators. Glutathione activity 14 (66.66%) 12 Serum free total Were higher acetylator (p < 0.02). Analysis resultspermitted us conclude that are related acetylatorphenotype. Furthermore, were always above 50 µg/ml, value considered therapeutic. deficiency observed 66% may be intestinal malabsorption nutrients, among them riboflavin, FAD precursor vitamin, inpatients paracoceidioidomycosis.
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