Development of a fluorescent chalcone library and its application in the discovery of a mouse embryonic stem cell probe.

作者： Sung-Chan Lee , Nam-Young Kang , Sung-Jin Park , Seong-Wook Yun , Yogeswari Chandran

关键词: Fluorescence 、 Cell biology 、 Chalcone 、 Molecular binding 、 Molecular biology 、 Chemistry 、 Intracellular 、 Stem cell 、 Small Molecule Libraries 、 Mouse Embryonic Stem Cell 、 Embryonic stem cell

摘要: We report the first fluorescent diamino-chalcone library and its application in discovery of a mouse embryonic stem cell (mESC) probe. CDg4, novel green mESC probe was discovered through high-content image based screening 160 members chalcone library. Interestingly, molecular binding target CDg4 identified as glycogen colony surface, rather than conventional protein from an intracellular source.

参考文章(29)

Amit R. Jagtap, Vijay S. Satam, Rajkumar N. Rajule, Vinod R. Kanetkar, Synthesis of highly fluorescent coumarinyl chalcones derived from 8-acetyl-1,4-diethyl-1,2,3,4-tetrahydro-7H-pyrano[2,3-g]quinoxalin-7-one and their spectral characteristics Dyes and Pigments. ,vol. 91, pp. 20- 25 ,(2011) , 10.1016/J.DYEPIG.2011.01.011

F. Huijing, A rapid enzymic method for glycogen estimation in very small tissue samples Clinica Chimica Acta. ,vol. 30, pp. 567- 572 ,(1970) , 10.1016/0009-8981(70)90246-9

Alan M. Myers, Matthew K. Morell, Martha G. James, Steven G. Ball, Recent progress toward understanding biosynthesis of the amylopectin crystal. Plant Physiology. ,vol. 122, pp. 989- 997 ,(2000) , 10.1104/PP.122.4.989

J LOMAKO, Glycogenin: The Primer for Mammalian and Yeast Glycogen Synthesis Biochimica et Biophysica Acta. ,vol. 1673, pp. 45- 55 ,(2004) , 10.1016/J.BBAGEN.2004.03.017

Bushra Mirza, Ahsan Ullah, Farzana Latif Ansari, Ihsan-ul-Haq, Samina Nazir, Combinatorial synthesis, lead identification, and antitumor study of a chalcone-based positional-scanning library. Chemistry & Biodiversity. ,vol. 4, pp. 203- 214 ,(2007) , 10.1002/CBDV.200790025

Pengfei Wang, Shikang Wu, Spectroscopy and photophysics of bridged enone derivatives: effect of molecular structure and solvent Journal of Photochemistry and Photobiology A: Chemistry. ,vol. 86, pp. 109- 113 ,(1995) , 10.1016/1010-6030(94)03921-G

Valérie Marchi-Artzner, Barbara Lorz, Charlie Gosse, Ludovic Jullien, Rudolf Merkel, Horst Kessler, Erich Sackmann, Adhesion of Arg-Gly-Asp (RGD) Peptide Vesicles onto an Integrin Surface: Visualization of the Segregation of RGD Ligands into the Adhesion Plaques by Fluorescence Langmuir. ,vol. 19, pp. 835- 841 ,(2003) , 10.1021/LA026227K

Knut Rurack, Julia L. Bricks, Günter Reck, Reiner Radeglia, Ute Resch-Genger, Chalcone-Analogue Dyes Emitting in the Near-Infrared (NIR): Influence of Donor−Acceptor Substitution and Cation Complexation on Their Spectroscopic Properties and X-ray Structure Journal of Physical Chemistry A. ,vol. 104, pp. 3087- 3109 ,(2000) , 10.1021/JP994269K

G.S.B. Viana, M.A.M. Bandeira, F.J.A. Matos, Analgesic and antiinflammatory effects of chalcones isolated from Myracrodruon urundeuva allemão. Phytomedicine. ,vol. 10, pp. 189- 195 ,(2003) , 10.1078/094471103321659924

10.

M. Gaber, T. A. Fayed, S. A. El-Daly, Y. S. El-Sayed, Spectral properties and inclusion of a hetero-chalcone analogue in organized media of micellar solutions and beta-cyclodextrin Photochemical and Photobiological Sciences. ,vol. 7, pp. 257- 262 ,(2008) , 10.1039/B713381B

Development of a fluorescent chalcone library and its application in the discovery of a mouse embryonic stem cell probe.

来源期刊

我的账户

Development of a fluorescent chalcone library and its application in the discovery of a mouse embryonic stem cell probe.

来源期刊

相似文章 10

我的账户