Correlation of [3H]diazepam binding density with anxiolytic locus in the amygdaloid complex of the rat

作者: Stephen R. Thomas , Michael E. Lewis , Susan D. Iversen

DOI: 10.1016/0006-8993(85)91355-1

关键词: AnxiolyticNeuroscienceChlordiazepoxideForebrainConditioned emotional responseAmygdalaBenzodiazepinePsychologyAversive StimulusDiazepam bindingDevelopmental biologyGeneral NeuroscienceMolecular biologyClinical neurology

摘要: Using [3H]diazepam binding, high concentrations of receptors were found in the frontal cortex and lateral amygdala. Infusions chlordiazepoxide into amygdala induced a release responding measured during component conditioned emotional response task previously associated with an aversive stimulus. The appears to be important forebrain circuitry involved expression anxiety sensitive benzodiazepine drugs.

参考文章(30)
Edmund T. Rolls, The brain and reward ,(1975)
Louis J. Pellegrino, Anna J. Cushman, A stereotaxic atlas of the rat brain Published in <b>1967</b> in New York NY) by Appleton-Century-Crofts. ,(1967)
Walle J. H. Nauta, Valerie B. Domesick, Crossroads of Limbic and Striatal Circuitry: Hypothalamo-Nigral Connections Springer, Boston, MA. pp. 75- 93 ,(1978) , 10.1007/978-1-4757-0716-8_6
M J Kuhar, W S Young, Radiohistochemical localization of benzodiazepine receptors in rat brain. Journal of Pharmacology and Experimental Therapeutics. ,vol. 212, pp. 337- 346 ,(1980)
L.W. Swanson, The hippocampus — new anatomical insights Trends in Neurosciences. ,vol. 2, pp. 9- 12 ,(1979) , 10.1016/0166-2236(79)90005-5
L. J. Porrino, A. M. Crane, P. S. Goldman-Rakic, Direct and indirect pathways from the amygdala to the frontal lobe in rhesus monkeys The Journal of Comparative Neurology. ,vol. 198, pp. 121- 136 ,(1981) , 10.1002/CNE.901980111
Sebastian P. Grossman, Lore Grossman, Linda Walsh, Functional organization of the rat amygdala with respect to avoidance behavior. Journal of Comparative and Physiological Psychology. ,vol. 88, pp. 829- 850 ,(1975) , 10.1037/H0076396
Marie-Hélène Thiébot, Antoinette Jobert, P. Soubrié, Conditioned suppression of behavior: its reversal by intra raphe microinjection of chlordiazepoxide and GABA. Neuroscience Letters. ,vol. 16, pp. 213- 217 ,(1980) , 10.1016/0304-3940(80)90347-X