5-HT1A and benzodiazepine receptors in the basolateral amygdala modulate anxiety in the social interaction test, but not in the elevated plus-maze

摘要: In order to investigate the role of 5-HT1A receptors amygdala in modulating anxiety, rats were implanted with bilateral cannulae aimed at basolateral nucleus complex and infused either artificial cerebrospinal fluid (aCSF) or selective receptor agonist 8-OH-DPAT (50-200 ng) tested two animal models anxiety. elevated plus-maze test, no significant effects detected this dose range. contrast, caused an overall reduction levels social investigation, thus indicating anxiogenic actions interaction test. At 50 ng, had a action on while 200 ng there was concomitant locomotor activity and, some animals, signs syndrome. Evidence that effect (50 due activation came from finding (-)-tertatolol, antagonist, reversed (1.5 micrograms) which silent when given alone. The benzodiazepine agonist, midazolam (1 2 bilaterally administered into evoked clear-cut anxiolytic These data indicate post-synaptic may produce effects, BDZ same areas evokes effects. Our results test are similar those previously reported tests anxiety using punished paradigms, but contrast found plus-maze. Thus, it is concluded have different sensitivities more intriguingly, evoking fundamentally states by being mediated via brain studied here.