Decellularized Renal Matrix and Regenerative Medicine of the Kidney: A Different Point of View.

摘要: Over the past years, extracellular matrix (ECM) obtained from whole organ decellularization has been investigated as a platform for engineering. The ECM is composed of fibrous and nonfibrous molecules providing structural biochemical support to surrounding cells. Multiple techniques, including ours, have optimized maintain composition, microstructure, biomechanical properties native renal that are difficult obtain during generation synthetic substrates. There evidences suggesting in vivo implanted capacity induce formation vasculature-like structures, but long-term transplantation filtration activity by these tissue-engineered constructs not or reported. Therefore, even if process possible, repopulation with functional cell types still very challenging. This review aims summarize current reports on kidney tissue engineering use decellularized matrices addresses challenges creating units. Finally, this discusses how future studies investigating cell-matrix interaction may aid unit would be transplantable into patients one day.