miRNA and target gene expression in menstrual endometria and early pregnancy decidua.
作者： Yang Lv , Shujun Gao , Yuanyuan Zhang , Liyan Wang , Xiujuan Chen
DOI: 10.1016/J.EJOGRB.2015.11.003
关键词: Immediate early protein 、 microRNA 、 Decidua 、 Decidualization 、 Gene expression 、 Medicine 、 Pregnancy 、 Andrology 、 Endometrium 、 Gynecology 、 Regulation of gene expression
摘要: Abstract Objective The role of miRNAs in modulating gene expression decidualization remains to be determined. We performed a comparative study identify and their potential mRNA targets with different levels between endometrium decidua. Methods Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used measure the miR-146b-5p, miR-181b-5p, miR-424, miR-532, miR-199a-3p, miR-423, miR-22-3p, let-7i-5p, miR-1 predicted target genes IGF2R , LEPR SGK1 MMP2 MMP10 LIF IL6 STAT3 menstrual endometria early pregnancy Results miR-199a-3p were significantly downregulated decidua, while upregulated. In addition, decidua had lower higher PROK1 than group. Conclusion Our results provide new insights into that regulate involved maintenance pregnancy.
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