High Frequency of Cryptic Deleterious Mutations in Caenorhabditis elegans
作者： Esther K Davies , Andrew D Peters , Peter D Keightley
DOI: 10.1126/SCIENCE.285.5434.1748
关键词: Point mutation 、 Mutational meltdown 、 Evolution of sexual reproduction 、 Caenorhabditis elegans 、 Gene 、 Phenotype 、 Genetic load 、 Genetics 、 Mutation 、 Biology 、 Multidisciplinary
摘要: Deleterious mutations with very small phenotypic effects could be important for several evolutionary phenomena, but the extent of their contribution has been unknown. Fitness induced in lines Caenorhabditis elegans were measured using a system which number deleterious point DNA can estimated. In fitness assays, only about 4 percent fixed each line detectable. The remaining 96 percent, though cryptic, are significant mutation load and, potentially, evolution sex.
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