Neural and Behavioral Predictors of Treatment Efficacy on Mood Symptoms and Cognition in Mood Disorders: A Systematic Review.

摘要: Background: The clinical and etiological heterogeneity of mood disorders impede identification effective treatments for the individual patient. This highlights a need early neuronal behavioral biomarkers treatment efficacy, which can provide basis more personalized treatments. present systematic review aimed to identify most consistent predictors efficacy on symptoms cognitive impairment in disorders. Methods: We identified included 60 original peer-reviewed studies investigating neuroimaging within domains emotional non-emotional cognition, structural neuroimaging, resting state functional connectivity patients with unipolar or bipolar disorder. Results: Lower baseline responsivity limbic regions coupled heightened medial dorsal prefrontal responses stimuli were response pharmacotherapy depression. In contrast, ventral reactivity seemed predict psychological interventions. Early modulation fronto-limbic activity reduction negative bias also associated response. Better performance tests at was relatively consistently symptoms, whereas association between neural during less clear. Other factors greater white matter integrity, connectivity, gray volume as well an increase following short administered treatment. Finally, emerging evidence indicates that deficits are chances achieving cognition. Conclusions: Patients' profile cognition activity-and treatment-associated changes function-may be useful guiding While seem improve this urgently needed.