Endocrine responses to insulin hypoglycaemia in the young calf.

摘要: 1. Variations in the output of glucocorticoids and catecholamines from right adrenal gland, response to insulin hypoglycaemia, have been investigated calves 2-5 weeks after birth. These correlated with changes concentration glucagon arterial plasma. 2. Moderate hypoglycaemia for a limited period (0-1 u. insulin/kg), elicited prompt increase steroid gland followed by significant rise plasma concentration. By comparison, both catecholamine peripheral glucocorticoid concentrations were found be trivial this group animals. 3. Administration larger dose (0-5 u./kg) produced more substantial fall glucose spontaneous recovery within 2-3 hr. This stimulus release greater amounts cortisol corticosterone, adrenaline Increase was accompanied an blood flow associated elevated steroids 4. The cortical transient even persistent intense (4 insulin/kg). animals not significantly than that smaller doses insulin. However, (78 plus or minus 14 ng. kg-minus 1 min-minus 1; maximum; n equals 9) together little noradrenaline (10 3 ng.kg-minus released under these conditions. 5. Changes could related given 0-1 0-5 insulin/kg. In largest coincidentally rising but hyperaemia then persisted had subsided values normal range. 6. Calves (4-0 invariably collapsed convulsed hr, symptoms any particular endocrine response. No clinical signs observed other 7. results are discussed relation previous studies function species.