Rhazinilam-Leuconolam-Leuconoxine Alkaloids from Leuconotis griffithii.
作者： Chew-Yan Gan , Yun-Yee Low , Noel F. Thomas , Toh-Seok Kam
DOI: 10.1021/NP400214Y
关键词: Leuconolam 、 IC50 、 Rhazinilam 、 Indole test 、 Stereochemistry 、 Moderate activity 、 Biology 、 Leuconoxine 、 Cytotoxicity
摘要: Eight new indole alkaloids (1–8) belonging to the rhazinilam–leuconolam–leuconoxine group, in addition 52 other alkaloids, were isolated from stem-bark extract of Leuconotis griffithii, viz., nor-rhazinicine (1), 5,21-dihydrorhazinilam-N-oxide (2), 3,14-dehydroleuconolam (3), and leuconodines A–E (4–8). The structures these determined using NMR MS analyses some instances confirmed by X-ray diffraction analyses. Alkaloids 1, 5, 7 showed only moderate weak cytotoxicity toward KB cells (IC50 12–18 μg/mL), while 8 activity reversing MDR vincristine-resistant cells.
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