Dinitrosyl iron complexes with thiol-containing ligands as a base for developing drugs with diverse therapeutic activities: Physicochemical and biological substantiation

摘要: Dinitrosyl iron complexes (DNICs) with thiol-containing ligands occur in animal tissues as paramagnetic (EPR-active) mononuclear and diamagnetic (EPR-silent) binuclear species the presence of nitric oxide. They provide stabilization storage (within protein-bound DNICs) oxide, well its transport low-molecular-weight to biological targets serve donors not only oxide itself but also nitrosonium ion (NO+). The latter function determines ability DNICs S-nitrosylate various proteins. In this way, participate a wide range physiological biochemical processes. With respect high diverse level activity dose dependence DNICs, they mimic endogenous system. Taken together broad occurrence (predominantly form) tissues, fact points their role an “operating form” It is thought that drugs designed on basis can substantially improve efficiency modern medical practice.