Hepatic production of apolar aldehydes in rats with carbon tetrachloride-induced cirrhosis.
作者： Natàliae Ferré , Josefa Girona , Maria Cabré , Jorge Joven , Agnes La Ville
关键词: Chemistry 、 Hexanal 、 Endocrinology 、 Clinical chemistry 、 Fibrosis 、 Internal medicine 、 Malondialdehyde 、 Cirrhosis 、 Biochemistry 、 Hepatic fibrosis 、 Antioxidant 、 Carbon tetrachloride
摘要: The aim of this study was to identify apolar aldehydes in liver homogenates from rats with CCl4-induced cirrhosis and, as a corollary, the antioxidant effect zinc administration. performed five control and ten cirrhotic which were further sub-divided into two groups receive either standard diet or one supplemented zinc. percentage hepatic fibrosis, plasma malondialdehyde concentration alanine aminotransferase activity measured well following aldehydes: hexanal, octanal, decanal, 2-hexenal, 2-octenal, 2-nonenal, 2,4-heptadienal 2,4-decadienal. Of 10 rats, 4 had elevated concentrations highly toxic 2,4-dialkenals coincided higher fibrosis activity. These not observed group. Zinc administration associated reduction an amelioration on degree injury. In conclusion, demonstrates presence tissue whith cirrhosis. Results obtained would suggest that these particular may be related severity
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