Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.
作者： Lixia Zhao , Qiu-Lan Ma , Frédéric Calon , Marni E Harris-White , Fusheng Yang
DOI: 10.1038/NN1630
关键词: Alzheimer's disease 、 Neuroscientist 、 Neurodegeneration 、 Psychology 、 Cofilin 、 Genetically modified mouse 、 Neuroscience 、 Dendritic spine 、 Dendritic spine morphogenesis 、 Neuron
摘要: … in Alzheimer disease. Here, we show that PAK and its activity are markedly reduced in Alzheimer … with a potential causal role of PAK defects in cognitive deficits in Alzheimer disease. …
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sci-hub.se 参考文章(51)
K Ojika, S Mitake, A Hirano, Hirano bodies and Alzheimer's disease. Kaohsiung Journal of Medical Sciences. ,vol. 13, pp. 10- 18 ,(1997)
Silvia Arber, Freda A. Barbayannis, Hartwig Hanser, Corinna Schneider, Clement A. Stanyon, Ora Bernard, Pico Caroni, Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase Nature. ,vol. 393, pp. 805- 809 ,(1998) , 10.1038/31729
Kristina M. Allen, Joseph G. Gleeson, Shubha Bagrodia, Michael W. Partington, John C. MacMillan, Richard A. Cerione, John C. Mulley, Christopher A. Walsh, PAK3 mutation in nonsyndromic X-linked mental retardation Nature Genetics. ,vol. 20, pp. 25- 30 ,(1998) , 10.1038/1675
Jamel Chelly, Jean-Louis Mandel, Monogenic causes of X-linked mental retardation Nature Reviews Genetics. ,vol. 2, pp. 669- 680 ,(2001) , 10.1038/35088558
Fusheng Yang, Xiaoyan Sun, Walter Beech, Bruce Teter, Sherry Wu, Jason Sigel, Harry V Vinters, Sally A Frautschy, Greg M Cole, None, Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. American Journal of Pathology. ,vol. 152, pp. 379- 389 ,(1998)
Donna L. McPhie, Robert Coopersmith, Andrew Hines-Peralta, Yuzhi Chen, Kathryn J. Ivins, Susan P. Manly, Michael R. Kozlowski, Kim A. Neve, Rachael L. Neve, DNA Synthesis and Neuronal Apoptosis Caused by Familial Alzheimer Disease Mutants of the Amyloid Precursor Protein Are Mediated by the p21 Activated Kinase PAK3 The Journal of Neuroscience. ,vol. 23, pp. 6914- 6927 ,(2003) , 10.1523/JNEUROSCI.23-17-06914.2003
Laurie S. Minamide, Amanda M. Striegl, Judith A. Boyle, Peter J. Meberg, James R. Bamburg, Neurodegenerative stimuli induce persistent ADF/cofilin-actin rods that disrupt distal neurite function. Nature Cell Biology. ,vol. 2, pp. 628- 636 ,(2000) , 10.1038/35023579
Dave Morgan, David M. Diamond, Paul E. Gottschall, Kenneth E. Ugen, Chad Dickey, John Hardy, Karen Duff, Paul Jantzen, Giovanni DiCarlo, Donna Wilcock, Karen Connor, Jaime Hatcher, Caroline Hope, Marcia Gordon, Gary W. Arendash, A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. ,vol. 408, pp. 982- 985 ,(2000) , 10.1038/35050116
Neng Yang, Osamu Higuchi, Kazumasa Ohashi, Kyoko Nagata, Atsushi Wada, Kenji Kangawa, Eisuke Nishida, Kensaku Mizuno, Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization Nature. ,vol. 393, pp. 809- 812 ,(1998) , 10.1038/31735
Linda A. Kotilinek, Brian Bacskai, Marcus Westerman, Takeshi Kawarabayashi, Linda Younkin, Bradley T. Hyman, Steven Younkin, Karen H. Ashe, Reversible memory loss in a mouse transgenic model of Alzheimer's disease. The Journal of Neuroscience. ,vol. 22, pp. 6331- 6335 ,(2002) , 10.1523/JNEUROSCI.22-15-06331.2002