The Clinical Significance of MiR-148a as a Predictive Biomarker in Patients with Advanced Colorectal Cancer
作者： Masanobu Takahashi , Miriam Cuatrecasas , Francesc Balaguer , Keun Hur , Yuji Toiyama
DOI: 10.1371/JOURNAL.PONE.0046684
关键词: Malignancy 、 Clinical significance 、 Oncology 、 Colorectal cancer 、 DNA methylation 、 Internal medicine 、 Cohort 、 Disease 、 Oxaliplatin 、 Medicine 、 Stage (cooking) 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Aim Development of robust prognostic and/or predictive biomarkers in patients with colorectal cancer (CRC) is imperative for advancing treatment strategies this disease. We aimed to determine whether expression status certain miRNAs might have prognostic/predictive value CRC treated conventional cytotoxic chemotherapies. Methods We studied a cohort 273 specimens from stage II/III 5-fluorouracil-based adjuvant chemotherapy and IV subjected 5-fluorouracil oxaliplatin-based chemotherapy. In screening set (n = 44), 13 21 candidate were successfully quantified by multiplex quantitative RT-PCR. the validation comprising entire patient cohort, miR-148a was assessed RT-PCR, its promoter methylation bisulfite pyrosequencing. Lastly, we analyzed associations between survival. Results Among studied, most significantly down-regulated advanced tissues. III CRC, low associated shorter disease free-survival (DFS), worse therapeutic response, poor overall survival (OS). Furthermore, correlated inversely expression, CRC. multivariate analysis, an independent biomarker (DFS III, vs. high HR 2.11; OS IV, 1.93). Discussion MiR-148a has chemotherapy, which important clinical implications improving personalized management malignancy.
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researchgate.net 参考文章(49)
Sohail F. Tavazoie, Claudio Alarcón, Thordur Oskarsson, David Padua, Qiongqing Wang, Paula D. Bos, William L. Gerald, Joan Massagué, Endogenous human microRNAs that suppress breast cancer metastasis Nature. ,vol. 451, pp. 147- 152 ,(2008) , 10.1038/NATURE06487
Scott Valastyan, Ferenc Reinhardt, Nathan Benaich, Diana Calogrias, Attila M Szász, Zhigang C Wang, Jane E Brock, Andrea L Richardson, Robert A Weinberg, None, RETRACTED: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis Cell. ,vol. 137, pp. 1032- 1046 ,(2009) , 10.1016/J.CELL.2009.03.047
Jin Sung Jang, Vernadette A Simon, Rod M Feddersen, Fariborz Rakhshan, Debra A Schultz, Michael A Zschunke, Wilma L Lingle, Christopher P Kolbert, Jin Jen, None, Quantitative miRNA Expression Analysis Using Fluidigm Microfluidics Dynamic Arrays BMC Genomics. ,vol. 12, pp. 144- 144 ,(2011) , 10.1186/1471-2164-12-144
Yue Chen, Yongxi Song, Zhenning Wang, Zhenyu Yue, Huimian Xu, Chengzhong Xing, Zhuangkai Liu, Altered Expression of MiR-148a and MiR-152 in Gastrointestinal Cancers and Its Clinical Significance Journal of Gastrointestinal Surgery. ,vol. 14, pp. 1170- 1179 ,(2010) , 10.1007/S11605-010-1202-2
George A. Calin, Carlo M. Croce, MicroRNA signatures in human cancers Nature Reviews Cancer. ,vol. 6, pp. 857- 866 ,(2006) , 10.1038/NRC1997
Richard Hummel, David I Watson, Cameron Smith, Jakob Kist, Michael Z Michael, Joerg Haier, Damian J Hussey, None, Mir-148a Improves Response to Chemotherapy in Sensitive and Resistant Oesophageal Adenocarcinoma and Squamous Cell Carcinoma Cells Journal of Gastrointestinal Surgery. ,vol. 15, pp. 429- 438 ,(2011) , 10.1007/S11605-011-1418-9
Miriam Koopman, Sabine Venderbosch, Iris D. Nagtegaal, Johan H. van Krieken, Cornelis J. Punt, A review on the use of molecular markers of cytotoxic therapy for colorectal cancer, what have we learned? European Journal of Cancer. ,vol. 45, pp. 1935- 1949 ,(2009) , 10.1016/J.EJCA.2009.04.023
Sven-T Liffers, Johanna B Munding, Markus Vogt, Jan D Kuhlmann, Berlinda Verdoodt, Sandeep Nambiar, Abdelouahid Maghnouj, Alireza Mirmohammadsadegh, Stephan A Hahn, Andrea Tannapfel, MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B Laboratory Investigation. ,vol. 91, pp. 1472- 1479 ,(2011) , 10.1038/LABINVEST.2011.99
H Zhang, Y Li, Q Huang, X Ren, H Hu, H Sheng, M Lai, MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer. Cell Death & Differentiation. ,vol. 18, pp. 1702- 1710 ,(2011) , 10.1038/CDD.2011.28
Francesc Balaguer, Alexander Link, Juan Jose Lozano, Miriam Cuatrecasas, Takeshi Nagasaka, C. Richard Boland, Ajay Goel, Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis Cancer Research. ,vol. 70, pp. 6609- 6618 ,(2010) , 10.1158/0008-5472.CAN-10-0622