Diabetes and prediabetes in patients with hepatitis B residing in North America
作者： Mandana Khalili , Manuel Lombardero , Raymond T Chung , Norah A Terrault , Marc G Ghany
DOI: 10.1002/HEP.28110
关键词: Prediabetes 、 Population 、 Impaired fasting glucose 、 Median body 、 Hepatitis B 、 Endocrinology 、 Internal medicine 、 Odds ratio 、 Diabetes mellitus 、 Diabetes risk 、 Medicine
摘要: Diabetes is associated with liver disease progression and increased hepatocellular carcinoma risk, but factors diabetes in patients chronic hepatitis B virus (HBV) infection North America are unknown. We aimed to determine predictive of impaired fasting glucose (IFG) a large HBV-infected multiethnic cohort. Adults HBV not receiving antiviral therapy were enrolled from 21 centers America. was defined by history/medication use or ≥126 mg/dL IFG as 100-125 mg/dL. Of 882 included, 47.2% female, 71.3% Asian, 83.7% foreign born, median age 44 years, body mass index BMI 24.3 kg/m2. In this cohort, 26.0% envelope antigen (HBeAg) positive, 43.9% had DNA ≥20,000 IU/mL, 26.7% alanine aminotransferase (ALT) ≥2× upper limit normal (≥40 U/L women, ≥60 men). Overall, 12.5% 7.8% IFG. The combined prevalence highest among blacks (36.7%) those either born the United States/Canada migration >20 years ago (25.5%). Obesity (odds ratio [OR]: 2.13), hyperlipidemia (OR, 4.13), hypertension 3.67), high ALT level 1.86), family history 3.43) diabetes. Factors obesity 4.13) 3.27), also HBeAg positivity 0.39). Recent negatively non-Asians 0.30). Conclusions: more prevalent American adults than general population known metabolic risk damage, determined levels. Among longer duration residence predicted non-Asians. These results highlight opportunities for interventions prevent especially at-risk ethnic groups HBV. (Hepatology 2015;62:1364–1374)
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