Hepatocellular carcinoma in the absence of cirrhosis in patients with chronic hepatitis B virus infection.
作者： Maneerat Chayanupatkul , Ronald Omino , Sahil Mittal , Jennifer R. Kramer , Peter Richardson
DOI: 10.1016/J.JHEP.2016.09.013
关键词:
摘要: Background & Aims Cirrhosis related to chronic hepatitis B (CHB) is a major risk factor for hepatocellular carcinoma (HCC). The extent which HCC occurs in U.S. the absence of cirrhosis CHB remains unclear. Methods We identified patients who were diagnosed with national Veterans Administration (VA) between 2001 and 2013. defined presence at time diagnosis using explicit histological, radiological, endoscopic, laboratory criteria. used multivariable regression analysis identify demographic clinical characteristics associated CHB-related cirrhosis. also examined liver transplant-free survival CHB-HCC without Results Among 8539 patients, 317 developed whom 30 (9.5%) did not have any evidence diagnosis. Compared cirrhosis, more likely be non-white (African American, OR=6.78; 95% CI 2.05–22.4; Asian, OR 11.6, 2.63–50.8), family history (OR 32.9, 3.76–288), hypertension 3.15, 1.02–9.75). There was no significant difference (hazard ratio 0.68, 0.43–1.09). Conclusions Fewer than 10% based Race main factors CHB. These may help guide decision initiate surveillance Lay summary Patients are African or older 40years age members cancer high blood pressure higher developing should included screening program cancer.
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