Hemodynamic Effects of Adalat in the Unanesthetized Dog

摘要: The effect of a drug on the cardiovascular system is determined not only by its principal mechanism action vascular smooth muscle and myocardium, but also secondary activation several control mechanisms. vasodilator Ca-antagonistic compound such as Adalat will necessarily induce reflex baroreceptor activation. According to recent literature, supramedullary regions in central nervous are involved pathways (Korner [1]). These connections known be more susceptible an anesthetic, however, than medulla oblongata itself (Peiss Manning [2]). In addition neurons medullary reticular formation anesthetized animal—due varying degrees preparative trauma—receive viscero-somatic afferent input present under physiological conditions. This poorly controlled “non-specific” input, which usually has generalized activating sympathetic efferents, may lead alterations set point gain order facilitate application results obtained from animals man, experiment trained conscious dog seems great advantage (Rushmer et al. [3]). We therefore studied effects coronary systemic hemodynamics dog.