Opportunistic invasive fungal disease in patients with type 2 diabetes mellitus from Southern China: Clinical features and associated factors.

摘要: AIMS/INTRODUCTION A retrospective study was carried out to investigate the clinical characteristics and associated factors for invasive fungal disease in patients with type 2 diabetes mellitus. MATERIALS AND METHODS Demographic data were recorded. Associated analyzed by logistic regression analysis. RESULTS Invasive diagnosed 120 mellitus (prevalence, 0.4%). Yeast infection (56/120, 46.7%), including candidiasis (31/56, 55.4%) cryptococcosis (25/56, 44.6%), most common. The urinary tract mainly involved (12/31, 38.7%). More than half of (16/25, 64.0%) presented as pneumonia. Mold accounted 40.8% cases, predominantly lung (34/49, 69.4%). total 15 (12.5%) had mixed infection. Candida albicans (24/111, 21.6%), Cryptococcus neoformans (19/111, 17.1%) Aspergillus fumigatus (14/111, 12.6%) leading agents. Co-infection occurred 58 (48.3%) patients, presenting pneumonia caused Gram-negative bacteria. inpatient mortality rate 23.3% (28/120). Glycated hemoglobin levels higher non-survivors survivors (8.8 ± 2.5 vs 7.7 ± 2.1%, P = 0.02). Anemia (adjusted odds ratio, 3.50, 95% confidence interval 1.95-6.27, P < 0.001), hypoalbuminemia 5.42, 3.14-9.36, P < 0.001) elevated serum creatinine 2.08, 1.07-4.04, P = 0.03) patients. CONCLUSIONS is a life-threatening complication C. a albicans, C. neoformans, A. fumigatus are Prolonged hyperglycemia results unfavorable outcomes. Correction anemia might improve prognosis.