Association between p53 codon 72 polymorphism and cervical cancer risk among Asians: a HuGE review and meta-analysis.

摘要: Objective: The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to derive a more precise estimation the association between p53 codon 72 polymorphism (Arg72Pro, rs1042522 G>C) cervical cancer risk among Asians. Methods: A literature search Pubmed, Embase, Web Science CBM databases from inception through June 2012 conducted. performed using STATA 12.0 software. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used assess strength any association. Twenty-eight case-control studies included total 3,580 cases 3,827 healthy controls. When all eligible pooled into meta-analysis, results showed that Pro/Pro genotype associated increased under heterozygous model (Pro/ Pro vs. Arg/Pro: OR = 1.25, 95%CI: 1.02-1.53, P= 0.005). However, no statistically significant associations found four other genetic models (Pro Arg: 0.97, 0.85-1.10, 0.624; + Arg/ Arg/Arg: 0.84, 0.70-1.01, 0.058; Arg/Arg 1.13, 0.92-1.39, 0.242; 0.76-1.22, 0.765; respectively). In subgroup analysis based on country, carrier Indian populations, but not Chinese, Japanese Korean populations. Conclusion: Results current suggests might be cancer, especially Indians.