Polymorphisms in HPV E6/E7 protein interacted genes and risk of cervical cancer in Chinese women: a case-control analysis.
作者： Xiaoyi Zhou , Suping Han , Sumin Wang , Xiaojun Chen , Jing Dong
DOI: 10.1016/J.YGYNO.2009.05.011
关键词: Logistic regression 、 Single-nucleotide polymorphism 、 Gynecology 、 Cervix 、 Case-control study 、 Cervical cancer 、 Oncology 、 Gene 、 Genotype 、 Genetic model 、 Internal medicine 、 Medicine
摘要: Abstract Objective Accumulating studies indicate that HPV E6/E7 oncoproteins interacting genes, TP53 , BRCA1 and BARD1 play a critical role in cervical carcinogenesis. We hypothesized potentially functional polymorphisms BRAD1 may individually and/or jointly contribute to cancer risk. Methods genotyped 4 single nucleotide (SNPs) with amino acid changes, Pro72Arg (rs1042522), Pro871Leu (rs799917), Pro24Ser (rs1048108) Arg378Ser (rs2229571), case-control study of 404 cases cancer-free controls Chinese women. Results Logistic regression analysis showed the variant rs799917 TT genotype was associated significantly decreased risk recessive genetic model (adjusted OR=0.62, 95% CI=0.40–0.95), compared genotypes CT/CC. However, no significant associations were observed for other 3 SNPs OR=1.01, CI=0.68–1.50 rs1048108 vs CT/CC; adjusted OR=1.04, CI=0.67–1.64 rs2229571 CC GG/GC; OR=0.84, CI=0.59–1.20 rs1042522 GG/GC). Conclusion These findings polymorphism this population, further validation populations are warranted.
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sci-hub.se 参考文章(33)
D T Bishop, D F Easton, D Ford, Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. American Journal of Human Genetics. ,vol. 56, pp. 265- 271 ,(1995)
Alan Storey, Miranda Thomas, Ann Kalita, Catherine Harwood, Daniela Gardiol, Fiamma Mantovani, Judith Breuer, Irene M. Leigh, Greg Matlashewski, Lawrence Banks, Role of a p53 polymorphism in the development of human papillomavirus-associated cancer. Nature. ,vol. 393, pp. 229- 234 ,(1998) , 10.1038/30400
YuLi Chai, Jian-qi Cui, Ningsheng Shao, E Shyam P Reddy, Veena N Rao, The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter. Oncogene. ,vol. 18, pp. 263- 268 ,(1999) , 10.1038/SJ.ONC.1202323
Richard Roden, T.-C. Wu, How will HPV vaccines affect cervical cancer Nature Reviews Cancer. ,vol. 6, pp. 753- 763 ,(2006) , 10.1038/NRC1973
A.M. Santos, D. Pinto, A.L. Pinto-Correia, D. Fontoura, J. Moutinho, R. Medeiros, S. Oliveira, H. Sousa, The p53 R72P polymorphism does not influence cervical cancer development in a Portuguese population: a study in exfoliated cervical cells. Journal of Medical Virology. ,vol. 80, pp. 424- 429 ,(2008) , 10.1002/JMV.21103
Jan M. M. Walboomers, Marcel V. Jacobs, M. Michele Manos, F. Xavier Bosch, J. Alain Kummer, Keerti V. Shah, Peter J. F. Snijders, Julian Peto, Chris J. L. M. Meijer, Nubia Mu�oz, Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. The Journal of Pathology. ,vol. 189, pp. 12- 19 ,(1999) , 10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F
Xiang Huo, Zhibin Hu, Xiangjun Zhai, Yan Wang, Shui Wang, Xuechen Wang, Jianwei Qin, Wenseng Chen, Guangfu Jin, Jiyong Liu, Jun Gao, Qingyi Wei, Xinru Wang, Hongbing Shen, None, Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain ( BARD1 ) gene are associated with breast cancer susceptibility: a case-control analysis Breast Cancer Research and Treatment. ,vol. 102, pp. 329- 337 ,(2007) , 10.1007/S10549-006-9332-7
Hongbing Zhang, Kumaravel Somasundaram, Yi Peng, Hui Tian, Hongxiang Zhang, Daike Bi, Barbara L Weber, Wafik S El-Deiry, BRCA1 physically associates with p53 and stimulates its transcriptional activity Oncogene. ,vol. 16, pp. 1713- 1721 ,(1998) , 10.1038/SJ.ONC.1201932
D. M. Parkin, F. Bray, J. Ferlay, P. Pisani, Global cancer statistics, 2002. CA: A Cancer Journal for Clinicians. ,vol. 55, pp. 74- 108 ,(2005) , 10.3322/CANJCLIN.55.2.74
Kentaro Miyai, Yoshiaki Furugen, Toshiharu Matsumoto, Keiichi Iwabuchi, Sachiko Hirose, Katsuyuki Kinoshita, Hiroaki Fujii, Loss of heterozygosity analysis in uterine cervical adenocarcinoma. Gynecologic Oncology. ,vol. 94, pp. 115- 120 ,(2004) , 10.1016/J.YGYNO.2004.04.013