Reduced placental taurine transporter (TauT) activity in pregnancies complicated by pre-eclampsia and maternal obesity.
作者： Michelle Desforges , Andrea Ditchfield , Chloe R. Hirst , Claire Pegorie , Kathryn Martyn-Smith
DOI: 10.1007/978-1-4614-6093-0_9
关键词: Eclampsia 、 Obesity 、 Pregnancy 、 Fetus 、 Endocrinology 、 Syncytiotrophoblast 、 Taurine 、 Complications of pregnancy 、 Medicine 、 Placenta 、 Internal medicine
摘要: Taurine is an important nutrient in intrauterine life, being required for fetal organ development and cellular renewal of syncytiotrophoblast (STB), the transport epithelium placenta. As taurine conditionally essential human pregnancy, placental demand met by uptake from maternal blood into STB through activity TauT. Pre-eclampsia (PE) obesity are serious complications associated with growth restriction (FGR) abnormal STB, a major risk factor PE. Here we test hypothesis that TauT reduced PE compared to normal pregnancy.
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Niki Jakeman, Confidential enquiry into stillbirths and deaths in infancy. Nursing Children and Young People. ,vol. 10, pp. 6- 7 ,(1998) , 10.7748/PAED.10.10.6.S8
AK Mbah, JL Kornosky, S Kristensen, EM August, AP Alio, PJ Marty, V Belogolovkin, K Bruder, HM Salihu, Super‐obesity and risk for early and late pre‐eclampsia British Journal of Obstetrics and Gynaecology. ,vol. 117, pp. 997- 1004 ,(2010) , 10.1111/J.1471-0528.2010.02593.X
John A. Sturman, Taurine in development. Journal of Nutrition. ,vol. 118, pp. 1169- 1176 ,(1988) , 10.1093/JN/118.10.1169
Niki Katsiki, Maria Baltazi, Christos Savopoulos, Fotios Iliadis, Apostolos I Hatzitolios, George Koliakos, Plasma neuropeptide Y (NPY) and alpha-melanocyte stimulating hormone (a-MSH) levels in patients with or without hypertension and/or obesity: a pilot study. American journal of cardiovascular disease. ,vol. 1, pp. 48- 59 ,(2011)
X. Han, A. B. Patters, D. P. Jones, I. Zelikovic, R. W. Chesney, The taurine transporter: mechanisms of regulation. Acta Physiologica. ,vol. 187, pp. 61- 73 ,(2006) , 10.1111/J.1748-1716.2006.01573.X
J.C. Challier, S. Basu, T. Bintein, J. Minium, K. Hotmire, P.M. Catalano, S. Hauguel-de Mouzon, Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta. ,vol. 29, pp. 274- 281 ,(2008) , 10.1016/J.PLACENTA.2007.12.010
Ellen Aagaard Nohr, Bodil Hammer Bech, Michael John Davies, Morten Frydenberg, Tine Brink Henriksen, Jorn Olsen, None, Prepregnancy obesity and fetal death: a study within the Danish National Birth Cohort. Obstetrics & Gynecology. ,vol. 106, pp. 250- 259 ,(2005) , 10.1097/01.AOG.0000172422.81496.57
Irene Cetin, Carlo Corbetta, Lucia P. Sereni, Anna Maria Marconi, Patrizia Bozzetti, Giorgio Pardi, Frederick C. Battaglia, Umbilical amino acid concentrations in normal and growth-retarded fetuses sampled in utero by cordocentesis American Journal of Obstetrics and Gynecology. ,vol. 162, pp. 253- 261 ,(1990) , 10.1016/0002-9378(90)90860-A
Gerald Gaull, John A Sturman, Niels C R Räihä, Development of mammalian sulfur metabolism: absence of cystathionase in human fetal tissues. Pediatric Research. ,vol. 6, pp. 538- 547 ,(1972) , 10.1203/00006450-197206000-00002
C. Tertrin-Clary, M.C. Chenut, P. De la Llosa, Isolation and characterization of protein kinase C from human placenta. Placenta. ,vol. 11, pp. 27- 33 ,(1990) , 10.1016/S0143-4004(05)80440-0