Effect of cysteamine on somatostatin-like immunoreactivity in the amygdala-kindled rat brain
作者： A. Pitkänen , J-M. Hyttinen , P.J. Riekkinen
DOI: 10.1016/0143-4179(89)90028-0
关键词: Striatum 、 Seizure threshold 、 Hypothalamus 、 Neuropeptide 、 Internal medicine 、 Endocrinology 、 Kindling 、 Amygdala 、 Piriform cortex 、 Medicine 、 Somatostatin
摘要: Previous studies have shown that a somatostatin-depleting drug, cysteamine (CYS), suppresses kindled seizures. However, no data is available concerning the levels of somatostatin-like immunoreactivity (SLI) in rat brain after CYS administration. In present study, we used radioimmunoassay to measure SLI frontal cortex, amygdala + piriform hippocampus, striatum and hypothalamus: 1) control rats, 2) amygdala-kindled rats decapitated 14 days last stimulus, 3) stimulus but treated either 11 or 4) 4 hours before decapitation with (100 mg/kg, subcutaneously). The results showed that, compared controls, was elevated both ipsi lateral (28%, p = 0.0372) contralateral (17%, 0.0078) cortex. Compared given decreased cortex (to 71%, 0.0066) hippocampus 72%, 0.0027), only hippocampus. decapitation, did not differ from controls rats. conclusion, somatostatinergic system affected amygdala-kindling; relationship anatomical localization magnitude CYS-induced decrease seizure threshold needs be studied further.
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sci-hub.se 参考文章(30)
SM Sagar, D Landry, WJ Millard, TM Badger, MA Arnold, JB Martin, Depletion of somatostatin-like immunoreactivity in the rat central nervous system by cysteamine The Journal of Neuroscience. ,vol. 2, pp. 225- 231 ,(1982) , 10.1523/JNEUROSCI.02-02-00225.1982
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
GRAHAM V. GODDARD, Development of Epileptic Seizures through Brain Stimulation at Low Intensity Nature. ,vol. 214, pp. 1020- 1021 ,(1967) , 10.1038/2141020A0
Asla Pitkänen, Jouni Sirviö, Jukka Jolkkonen, Paavo Riekkinen, Somatostatin-like immunoreactivity and somatostatin receptor binding in rat brain before and after pentylenetetrazol-induced convulsion. Neuropeptides. ,vol. 7, pp. 63- 71 ,(1986) , 10.1016/0143-4179(86)90080-6
G. Sperk, R. Wieser, R. Widmann, E.A. Singer, Kainic acid induced seizures: changes in somatostatin, substance P and neurotensin. Neuroscience. ,vol. 17, pp. 1117- 1126 ,(1986) , 10.1016/0306-4522(86)90081-3
L. Steardo, P. Barone, E. Hunnicutt, Carbamazepine lowering effect on CSF somatostatin‐like immunoreactivity in temporal lobe epileptics Acta Neurologica Scandinavica. ,vol. 74, pp. 140- 144 ,(1986) , 10.1111/J.1600-0404.1986.TB04640.X
G.F. Alheid, L. Heimer, New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: the striatopallidal, amygdaloid, and corticopetal components of substantia innominata. Neuroscience. ,vol. 27, pp. 1- 39 ,(1988) , 10.1016/0306-4522(88)90217-5
Georges Assouline, Edy Barkaie, Michael J. Gutnick, Cysteamine suppresses kindled seizures in pentylenetetrazol-kindled rats. European Journal of Pharmacology. ,vol. 106, pp. 649- 652 ,(1984) , 10.1016/0014-2999(84)90073-6
A. Pitkänen, J. Jolkkonen, P.J. Riekkinen, Somatostatin-like immunoreactivity (SLI) in cisternal cerebrospinal fluid of rats kindled by pentylenetetrazol Brain Research. ,vol. 416, pp. 180- 182 ,(1987) , 10.1016/0006-8993(87)91514-9
Q.J. Pittman, G.R. Siggins, Somatostatin hyperpolarizes hippocampal pyramidal cells in vitro Brain Research. ,vol. 221, pp. 402- 408 ,(1981) , 10.1016/0006-8993(81)90791-5